|The CSF2 csf2 (Catalog #MBS546106) is a Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase.
The CSF2 csf2 product has the following accession number(s) (GI #27437030) (NCBI Accession #NP_000749.2) (Uniprot Accession #P04141). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Our knowledge of the role of proteins in cellular processes is continually evolving. Most proteins, including Granulocyte Macrophage Colony Stimulating Factor are typically involved in one or more signaling pathways or biological processes. Professionally manufactured recombinant proteins are increasingly becoming essential and commonplace tools for elucidating new knowledge about the role of proteins in both health and disease.
Molecular Weight Information: Approximately 14.4 kDa, a single non-glycosylated polypeptide chain containing 127 amino acids. Biological Activity: Fully biologically active when compared to standard. The ED50 as calculated by the dose-dependant stimulation of the proliferation of human TF-1 cells is less then 0.1 ng/ml, corresponding to a Specific Activity of 1 x 107 IU/mg.
Endotoxin Level: Less than 1EU/mg of rHuGM-CSF as determined by LAL method.
Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20 degree C. Further dilutions should be made in appropriate buffered solutions. The following patways have been known to be associated with this gene. Arthritis, Rheumatoid, Breast Neoplasms, Carcinoma, Inflammation, Leukemia, Myeloid, Acute, Liver Diseases, Lung Diseases, Lung Neoplasms, Necrosis, Neoplasms are some of the diseases may be linked to Recombinant Human GranulocyteMacrophage Colony Stimulating Factor (rHu GM-CSF). Blood, Bone, Intestine, Lung tissues are correlated with this protein. CSF2 also interacts with the following gene(s): CSF2RA, CSF2RB, FOS, IL3, IL4, IL5, JAK2, SDC2, STAT3.