|The CXCL12 cxcl12 (Catalog #MBS651060) is a Recombinant Protein and is intended for research purposes only. The product is available for immediate purchase.
The CXCL12 cxcl12 product has the following accession number(s) (GI #10834988) (NCBI Accession #NP_000600.1) (Uniprot Accession #P48061). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Stromal Cell Derived Factor 1 beta, Recombinant, Mouse (SDF1b, CXCL12b, Pre-B Cell Growth-stimulating Factor, PBSF, hIRH, Chemokine (C-X-C Motif) Ligand 12b, TPAR1, SCYB12, TLSF-b)
Our knowledge of the role of proteins in cellular processes is continually evolving. Most proteins, including Stromal Cell Derived Factor 1 beta are typically involved in one or more signaling pathways or biological processes. Professionally manufactured recombinant proteins are increasingly becoming essential and commonplace tools for elucidating new knowledge about the role of proteins in both health and disease.
Biological Activity: Determined measuring dose-dependent chemotaxis with human peripheral blood monocytes. A concentration range of 50-100ng/ml produced significant chemotaxis. SDF-1 is a CXC chemokine that binds to the chemokine receptor CXCR4. SDF-1 is widely expressed by cells of most tissues, including bone marrow stromal cells. SDF-1 is a chemoattractant for mononuclear cells and CD34+ hematopoietic progenitor cells.
Endotoxin Level: 0.1ng/ug. Bone, Bone Marrow, Brain, Embryonic Tissue, Heart, Liver, Lung, Muscle, Spleen, Vascular tissues are correlated with this protein. CXCL12 also interacts with the following gene(s): CD4, CTSG, CXCR4, DPP4, FN1, MMP2. The following patways have been known to be associated with this gene. Breast Neoplasms, Carcinoma, Cardiovascular Diseases, Inflammation, Leukemia, Lymphoma, Myocardial Ischemia, Necrosis, Neoplasm Metastasis, Neoplasms are some of the diseases may be linked to Stromal Cell Derived Factor 1 beta, Recombinant, Mouse (SDF1b, CXCL12b, Pre-B Cell Growth-stimulating Factor, PBSF, hIRH, Chemokine (C-X-C Motif) Ligand 12b, TPAR1, SCYB12, TLSF-b).