HER3 / ErbB3 recombinant protein product blog
Tags: Recombinant Protein; HER3 / ERBB3; HER3 / ErbB3 recombinant protein;
The HER3 / ErbB3 erbb3 (Catalog #MBS2546418) is an Active Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase.The recombinant human ErbB3 protein consists of 635 amino acids after the removal of signal peptide and has a calculated molecular mass of 70.2 kDa. As a result of glycosylation, the recombinant ErbB3 migrates as an approximately 100-110 kDa band in SDS-PAGE under reducing conditions. Researchers should empirically determine the suitability of the HER3 / ErbB3 erbb3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The HER3 / ErbB3 erbb3 product has the following accession number(s) (GI #54792100) (NCBI Accession #NP_001973.2) (Uniprot Accession #P21860). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given active protein. We\'ve tested the Recombinant Human HER3 / ErbB3 Protein (His tag) with the following immunoassay(s):
SDS-PAGE
Our knowledge of the role of proteins in cellular processes is continually evolving. Most proteins, including HER3 / ErbB3 are typically involved in one or more signaling pathways or biological processes. Professionally manufactured recombinant proteins are increasingly becoming essential and commonplace tools for elucidating new knowledge about the role of proteins in both health and disease.
Source: Human
Predicted N Terminal: Ser 20
Bio-Activity: 1. Measured by its binding ability in a functional ELISA.
2. Immobilized human ErbB3 at 2 ug/mL (100 ul/well) can bind human NRG1 (isoform Beta1), The EC50 of human NRG1 (isoform Beta1) is 0.43 ug/mL. Endotoxin: < 1.0 EU per mug of the protein as determined by the LAL method
Reconstitution: It is recommended that sterile water (70 ul) be added to the vial to prepare a stock solution of 0.15 mg/mL.
Concentration is measured by UV-Vis. Adenocarcinoma, Breast Neoplasms, Carcinoma, Disease Models, Animal, Lung Neoplasms, Neoplasm Metastasis, Neoplasms, Experimental, Nervous System Diseases, Ovarian Neoplasms, Prostatic Neoplasms are some of the diseases may be linked to Recombinant Human HER3 / ErbB3 Protein (His tag). Brain, Embryonic Tissue, Heart, Liver, Lung, Mammary Gland, Muscle, Nerve, Prostate, Vascular tissues are correlated with this protein. HER3 / ErbB3 also interacts with the following gene(s): EGF, EGFR, ERBB2, GRB2, NRG1, NRG2, PA2G4, RNF41, SHC1. The following patways have been known to be associated with this gene.