IL10 protein product blog
Tags: Protein; Interleukin-10; IL10; IL10 protein;
The IL10 il10 (Catalog #MBS546087) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase.The IL10 il10 product has the following accession number(s) (GI #10835141) (NCBI Accession #NP_000563.1) (Uniprot Accession #P22301). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Our knowledge of the role of proteins in cellular processes is continually evolving. Most proteins, including Interleukin-10 are typically involved in one or more signaling pathways or biological processes. Professionally manufactured recombinant proteins are increasingly becoming essential and commonplace tools for elucidating new knowledge about the role of proteins in both health and disease.
Molecular Weight Information: Approximately 18.5 kDa, a single non-glycosylated polypeptide chain containing 172 amino acids. Biological Activity: Determined by the dose-dependent co-stimulation (with murine IL-4) of MC/9 cells. The ED50 was found to be <= 2 ng/ml, corresponding to a specific activity of >=5 x 105 units/mg.
Endotoxin Level: Less than 1EU/mg of rHuIL-10 as determined by LAL method.
Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20 degree C. Further dilutions should be made in appropriate buffered solutions. IL10 also interacts with the following gene(s): CD4, DIF, IL10RA, IL10RB, IL2, IL4, IL6, JUN, NOS2. The following patways have been known to be associated with this gene. Blood, Connective Tissue, Lung, Spleen, Uncharacterized Tissue tissues are correlated with this protein. Arthritis, Rheumatoid, Colitis, Genetic Predisposition to Disease, HIV Infections, Hypersensitivity, Immediate, Inflammation, Inflammatory Bowel Diseases, Kidney Diseases, Necrosis, Sepsis are some of the diseases may be linked to Recombinant Human Interleukin-10 (rHu IL-10).