|The IL2 il2 (Catalog #MBS538199) is a Recombinant Protein produced from Human and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s IL2 can be used in a range of immunoassay formats including, but not limited to, User optimized. Researchers should empirically determine the suitability of the IL2 il2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The IL2 il2 product has the following accession number(s) (GI #28178861) (NCBI Accession #NP_000577.2) (Uniprot Accession #P60568). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful. The amino acid sequence is listed below:
Region of IL2 protein correspond ing to amino acids MAPTSSSTKK TQLQLEHLLL DLQMILNGIN NYKNPKLTRM LTFKFYMPKK ATELKHLQCL EEELKPLEEV LNLAQSKNFH LRPRDLISNI NVIVLELKGS ETTFMCEYAD ETATIVEFLN RWITFCQSII STLT.
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Our knowledge of the role of proteins in cellular processes is continually evolving. Most proteins, including IL2 are typically involved in one or more signaling pathways or biological processes. Professionally manufactured recombinant proteins are increasingly becoming essential and commonplace tools for elucidating new knowledge about the role of proteins in both health and disease.
Protein Type: Recombinant
Biological Significance: IL2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL2/IL2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL2 stimulates growth and differentiation of B-cells, NK cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes.
Bioactivity: The ED50 as determined by the dose-dependent stimulation of Mouse CTLL-2 cells is approximately 0.1 ng/ml, corresponding to a specific activity of approximately 1 x 10^7 units/mg.
Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug). Expression System: E Coli. The following patways have been known to be associated with this gene. IL2 also interacts with the following gene(s): FOXP3, IL2RA, IL2RB, IL2RG, IL4, LCK, RELA, STAT5A, STAT5B. Blood, Uncharacterized Tissue tissues are correlated with this protein. HIV Infections, Inflammation, Kidney Diseases, Kidney Neoplasms, Leukemia, Liver Diseases, Lung Neoplasms, Melanoma, Necrosis, Neoplasms, Experimental are some of the diseases may be linked to IL2 protein.