IL4 recombinant protein product blog
Tags: IL4; Recombinant Protein; IL4 recombinant protein;
The IL4 il4 (Catalog #MBS538246) is an Active Protein produced from Human and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s IL4 can be used in a range of immunoassay formats including, but not limited to, User optimized. Researchers should empirically determine the suitability of the IL4 il4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The IL4 il4 product has the following accession number(s) (GI #55742622) (NCBI Accession #NP_999288.1) (Uniprot Accession #Q04745). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful. The amino acid sequence is listed below:
Region of IL4 protein correspond ing to amino acids MHKCDITLQE IIKTLNSLTE QKTLCTELTV TDIFAASKNT TEKETFCRAA TVLRQFYSHH EKDTRCLGAT AQQFHRHKQL IRFLKRLDRN LWGLAGLNSC PVKEANQSTL ENFLERLKTI MREKYSKCSS.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Our knowledge of the role of proteins in cellular processes is continually evolving. Most proteins, including IL4 are typically involved in one or more signaling pathways or biological processes. Professionally manufactured recombinant proteins are increasingly becoming essential and commonplace tools for elucidating new knowledge about the role of proteins in both health and disease.
Protein Type: Recombinant
Biological Significance: IL4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL4, IL5, IL6, IL10, and IL13, which favor a humoral immune response. Another dominant function of IL4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL4 production by Th2 cells has been associated with elevated IgE production and allergy.
Bioactivity: The ED50 as determined by the dose-dependent stimulation of human TF-1 cells is approximately 0.2 ng/ml, corresponding to a specific activity of approximately 5 x 10^6 units/mg.
Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug). Expression System: E Coli. Asthma, Autoimmune Diseases, Hypersensitivity, Hypersensitivity, Immediate, Inflammation, Liver Diseases, Lung Diseases, Necrosis, Respiratory Hypersensitivity, Rhinitis are some of the diseases may be linked to IL4 protein. IL4 also interacts with the following gene(s): CSF2, IL-5, IL13RA1, IL2RG, IL4R, JAK2, JAK3. The following patways have been known to be associated with this gene.