|The JAK2 jak2 (Catalog #MBS2011145) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s Janus Kinase 2 (JAK2) can be used in a range of immunoassay formats including, but not limited to, SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP). Researchers should empirically determine the suitability of the JAK2 jak2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The JAK2 jak2 product has the following accession number(s) (GI #4826776) (NCBI Accession #NP_004963.1) (Uniprot Accession #O60674). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful. The amino acid sequence is listed below:
The target protein is fused with N-terminal His-Tag, its sequence is listed below.
MGHHHHHHSG SEF-NLL VFRTNGVSDV PTSPTLQRPT HMNQMVFHKI RNEDLIFNES LGQGTFTKIF KGVRREVGDY GQLHETEVLL KVLDKAHRNY SESFFEAASM MSKLSHKHLV LNYGVCVCGD ENILVQEFVK FGSLDTYLKK NKNCINILWK LEVAKQLAWA MHFLEENTLI HGNVCAKNIL LIREEDRKTG NPPFIKLSDP GISITVLPKD ILQERIPWVP PECIENPKNL NLATDKWSFG TTLWEICSGG DKPLSALDSQ RKLQFYEDRH QLPAPKWAEL ANLINNCMDY EPDFRPSFRA.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Our knowledge of the role of proteins in cellular processes is continually evolving. Most proteins, including Janus Kinase 2 (JAK2) are typically involved in one or more signaling pathways or biological processes. Professionally manufactured recombinant proteins are increasingly becoming essential and commonplace tools for elucidating new knowledge about the role of proteins in both health and disease.
Organism: Homo sapiens (Human)
Expression System: Prokaryotic expression
Residues: Asn508~Ala800 (Accession # O60674) with N-terminal His-Tag. Endotoxin Level: <1.0EU per 1ug (determined by the LAL method)
Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4. JAK2 also interacts with the following gene(s): CSF2RB, EPOR, GHR, PRLR, PTPN11, SH2B1, SOCS1, SOCS3, STAT1, STAT3. The following patways have been known to be associated with this gene. Bone, Bone Marrow, Brain, Kidney, Liver, Lung, Mammary Gland, Muscle, Spleen, Vascular tissues are correlated with this protein. Cardiovascular Diseases, Inflammation, Leukemia, Leukemia, Myeloid, Acute, Neoplasms, Polycythemia, Polycythemia Vera, Primary Myelofibrosis, Thrombocythemia, Essential, Thrombocytosis are some of the diseases may be linked to Recombinant Janus Kinase 2 (JAK2).