Mitochondrial DNA Isolation Kit assay kit product blog
Tags: Assay Kit; Mitochondrial DNA Isolation Kit; Mitochondrial DNA Isolation Kit assay kit;
The Mitochondrial DNA Isolation Kit n/a (Catalog #MBS841727) is an Assay Kit and is intended for research purposes only. The product is available for immediate purchase.To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
(Or you can also download the PDF Manual for complete product instructions).
Background/Introduction: MEK1 is also known by a variety of other names. They include dual specificity mitogen-activated protein kinase kinase (MAP kinase kinase 1 or MAPKK 1), ERK activator kinase 1, MAPK/ERK kinase 1, ERK kinase 1 and MAP kinase kinase. MEK1 is a 393 amino acid, 43.5kD protein that is highly conserved in evolution3. MEK phosphorylates threonine and tyrosine residues on MAP kinases ERK 1 and 2 (p44 and p42 MAP kinase)4. MEK participates in a wide range of cellular processes including cell proliferation5, differentiation6 and apoptosis7. MEK 1/2 is activated by phosphorylation of Ser218 and Ser222 by the serine-threonine kinase RAF1, which is part of the p21ras signal transduction pathway. Constitutive activation of MEK 1/2 results in cellular transformation. This protein kinase has been reported to be a likely target for pharmacologic intervention in proliferative diseases8. Recent literature reviews cover MEK activity in great detail9-10.