|The Prl R prlr (Catalog #MBS143283) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase.
The Prl R prlr product has the following accession number(s) (GI #4506107) (NCBI Accession #NP_000940.1) (Uniprot Accession #P16471). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful. The amino acid sequence is listed below:
The sequence of the first six N-terminal amino acids was determined to be Ala-Gly-Ly s-Pro-Glu- Ile.
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Our knowledge of the role of proteins in cellular processes is continually evolving. Most proteins, including Prolactin are typically involved in one or more signaling pathways or biological processes. Professionally manufactured recombinant proteins are increasingly becoming essential and commonplace tools for elucidating new knowledge about the role of proteins in both health and disease.
Solubility: It is recommended to reconstitute the lyophilized PRLR in sterile 18M-cm H2O not less than 100 ug/ml and not more than 1 mg/ml, which can then be further diluted to other aqueous solutions.
Protein Content: UV spectroscopy at 280 nm using the absorbency value of 2.63 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics).
Biological Activity: Activity is determined by the dose-dependant inhibition of Prolactin stimuled proliferation of Nb2 cells and by high affinity binding of ovine Prolactin and other lactogenic hormones in 1:1 molar ratio. The following patways have been known to be associated with this gene. Brain, Connective Tissue, Intestine, Kidney, Liver, Mammary Gland, Ovary, Placenta, Prostate, Uterus tissues are correlated with this protein. Breast Neoplasms, Carcinoma, Infertility, Female, Inflammation, Liver Diseases, Mammary Neoplasms, Animal, Mammary Neoplasms, Experimental, Necrosis, Neoplasms, Experimental, Weight Gain are some of the diseases may be linked to Recombinant Human Prolactin Receptor.