|The SFRP4 sfrp4 (Catalog #MBS636038) is a Recombinant Protein and is intended for research purposes only. The product is available for immediate purchase.
The SFRP4 sfrp4 product has the following accession number(s) (GI #170784838) (NCBI Accession #NP_003005.2) (Uniprot Accession #Q6FHJ7). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Our knowledge of the role of proteins in cellular processes is continually evolving. Most proteins, including SFRP4 are typically involved in one or more signaling pathways or biological processes. Professionally manufactured recombinant proteins are increasingly becoming essential and commonplace tools for elucidating new knowledge about the role of proteins in both health and disease.
Activity: Measured by its ability to inhibit Wnt-3A\'s ability to induce alkaline phosphatase synthesis in the
presence of BMP-2 by MC3T3E1 osteoblastic cells. The ED50 for this effect is typically 4-20ug/ml, in the presence of 20ng/ml of rmWnt-3a.
Endotoxin Level: 1.0 EU per 1ug of the cytokine as determined by the LAL method. Reconstitution: Reconstitute with sterile PBS containing at least 0.1% human serum albumin or bovine serum albumin. Prepare a stock solution of no less than 10ug/ml. The following patways have been known to be associated with this gene. SFRP4 also interacts with the following gene(s): WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3A, WNT5A, WNT6, WNT7B, WNT9A. Bone, Brain, Connective Tissue, Eye, Kidney, Liver, Lung, Muscle, Ovary, Uterus tissues are correlated with this protein. Adenocarcinoma, Breast Neoplasms, Carcinoma, Cell Transformation, Neoplastic, Colorectal Neoplasms, Endocrine Gland Neoplasms, Endometrial Neoplasms, Neoplasms, Neoplasms, Experimental, Uterine Neoplasms are some of the diseases may be linked to SFRP4, Recombinant, Human (Secreted Frizzled Related Protein 4, DDC-4, FrpAP, frpHE, FrzB-2).