|The TLR-3 tlr3 (Catalog #MBS692016) is a Recombinant Protein produced from HEK 293 Cells and is intended for research purposes only. The product is available for immediate purchase. The Human TLR-3 reacts with Human and may cross-react with other species as described in the data sheet.
The TLR-3 tlr3 product has the following accession number(s) (GI #4507531) (NCBI Accession #NP_003256.1) (Uniprot Accession #O15455). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful. The amino acid sequence is listed below:
STTKCTVSHE VADCSHLKLT QVPDDLPTNI TVLNLTHNQL RRLPAA NFTR YSQLTSLDVG FNTISKLEPE LCQKLPMLKV LNLQHNELSQ L SDKTFAFCT NLTELHLMSN SIQKIKNNPF VKQKNLITLD LSHNGLS STK LGTQVQLENL QELLLSNNKI QALKSEELDI FANSSLKKLE LS SNQIKEFS PGCFHAIGRL FGLFLNNVQL GPSLTEKLCL ELANTSIR NL SLSNSQLSTT SNTTFLGLKW TNLTMLDLSY NNLNVVGNDS FAW LPQLEYF FLEYNNIQHL FSHSLHGLFN VRYLNLKRSF TKQSISLAS L PKIDDFSFQW LKCLEHLNME DNDIPGIKSN MFTGLINLKY LSLS NSFTSL RTLTNETFVS LAHSPLHILN LTKNKISKIE SDAFSWLGHL EVLDLGLNEI GQELTGQEWR GLENIFEIYL SYNKYLQLTR NSFAL VPSLQ RLMLRRVALK NVDSSPSPFQ PLRNLTILDL SNNNIANIND DMLEGLEKLE ILDLQHNNLA RLWKHANPGG PIYFLKGLSH LHILNL ESNG FDEIPVEVFK DLFELKIIDL GLNNLNTLPA SVFNNQVSLK S LNLQKNLIT SVEKKVFGPA FRNLTELDMR FNPFDCTCES IAWFVNW INE THTNIPELSS HYLCNTPPHY HGFPVRLFDT SSCKDSAPFE L.
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Our knowledge of the role of proteins in cellular processes is continually evolving. Most proteins, including TLR-3 are typically involved in one or more signaling pathways or biological processes. Professionally manufactured recombinant proteins are increasingly becoming essential and commonplace tools for elucidating new knowledge about the role of proteins in both health and disease.
Endotoxin Level: < 0.1 ng per ug of TLR-3. Biological Activity: Determined by its ability to inhibit IL-8 secretion induced by Poly I:C in the TLR3 receptor-expressing HEK293 cells (HEK293 TLR3r). The ED50for this effect is <= 30 ug/ml in the presence of 100 ug/ml of Poly I:C. Bone, Brain, Eye, Intestine, Kidney, Liver, Lung, Muscle, Skin, Spleen tissues are correlated with this protein. The following patways have been known to be associated with this gene. TLR-3 also interacts with the following gene(s): IKBKG, RIPK1, RIPK3, TAB2, TICAM1, TICAM2, TRAF6, UNC93B1, ZBP1. Adenocarcinoma, Carcinoma, Hepatocellular, Encephalitis, Herpes Simplex, Inflammation, Kidney Diseases, Lung Diseases, Necrosis, Neoplasms, Neoplasms, Experimental, Vascular Diseases are some of the diseases may be linked to Human TLR-3.