|The TNF tnf (Catalog #MBS637486) is a Recombinant Protein produced from Human, E Coli and is intended for research purposes only. The product is available for immediate purchase.
The TNF tnf product has the following accession number(s) (GI #37210) (NCBI Accession #CAA26669.1) (Uniprot Accession #P01375). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful. The amino acid sequence is listed below:
A FLAG®- tag is fused at the N-terminus of human TNF-alpha (aa 85-223).
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Our knowledge of the role of proteins in cellular processes is continually evolving. Most proteins, including TNF-alpha, Soluble are typically involved in one or more signaling pathways or biological processes. Professionally manufactured recombinant proteins are increasingly becoming essential and commonplace tools for elucidating new knowledge about the role of proteins in both health and disease.
Biological Activity: Induces cell death at a concentration range of 0.1-1 ng/ml (ED50=0.05 ng/ml or 2x10e7 units/mg; WEHI 164 cells)
Endotoxin: < 0.01 EU/ug protein (LAL)
. Atherosclerosis, Fibrosis, Inflammation, Insulin Resistance, Liver Diseases, Lung Diseases, Necrosis, Pain, Skin Diseases, Vascular Diseases are some of the diseases may be linked to TNF-alpha, Soluble, Recombinant, Human (Tumor Necrosis Factor Ligand Superfamily Member 2, Cachectin). TNF also interacts with the following gene(s): BIRC2, ICAM1, IL10, IL1B, IL6, RIPK1, TNFRSF1A, TNFRSF1B, TRADD, TRAF2. The following patways have been known to be associated with this gene. Blood, Brain, Connective Tissue, Heart, Intestine, Lung, Lymph Node, Ovary, Placenta, Prostate tissues are correlated with this protein.