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HSPA5 active protein product blog

Tags: HSPA5; GRP78 (Bip); Active Protein; HSPA5 active protein;

     The HSPA5 hspa5 (Catalog #MBS806942) is an Active Protein produced from Human and is intended for research purposes only. The product is available for immediate purchase. The Recombinant Human GRP78 (Bip) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Grp78 (Bip) can be used in a range of immunoassay formats including, but not limited to, ATPase Assay, Western Blot control (WB), Binding Assay, ELISA (EIA) reference standard. Researchers should empirically determine the suitability of the HSPA5 hspa5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The HSPA5 hspa5 product has the following accession number(s) (GI #16507237) (NCBI Accession #NP_005338.1) (Uniprot Accession #P11021). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Please refer to the product datasheet for known applications of a given active protein. We\'ve tested the Recombinant Human GRP78 (Bip) with the following immunoassay(s):
SDS-Page (SDS-PAGE of 78kDa Grp78 (Bip) protein (SPR-107).)

Our knowledge of the role of proteins in cellular processes is continually evolving. Most proteins, including Grp78 (Bip) are typically involved in one or more signaling pathways or biological processes. Professionally manufactured recombinant proteins are increasingly becoming essential and commonplace tools for elucidating new knowledge about the role of proteins in both health and disease.

Certificate of Analysis: This product has been certified >90% pure using SDS-PAGE analysis. The protein has ATPase activity at the time of manufacture of 2.3uM phosphate liberated/hr/ug protein in a 200ul reaction at 37 degree C (pH 8) in the presence of 20ul of 1mM ATP using a Malachite Green assay.
Conjugate Tag: His tag
Expression System: E Coli. Buffer: 20mM Tris, 50mM KCl, 5mM MgCl2, 1mM DTT, pH7.5
Cellular location: Endoplasmic reiculum lumen, Melanosome. Blood, Brain, Heart, Kidney, Liver, Lung, Muscle, Nerve, Pancreas, Vascular tissues are correlated with this protein. Cardiovascular Diseases, Disease Models, Animal, Fatty Liver, Fibrosis, Heart Diseases, Inflammation, Kidney Diseases, Liver Diseases, Necrosis, Nervous System Diseases are some of the diseases may be linked to Recombinant Human GRP78 (Bip). HSPA5 also interacts with the following gene(s): ATF4, ATF6, EIF2AK3, ERN1, HYOU1, SIL1. The following patways have been known to be associated with this gene.
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